RNF125 Antibody (PACO43476)
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주문- SKU:
- PACO43476
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RNF125 Antibody (PACO43476) |
Antibody SKU: | PACO43476 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human E3 ubiquitin-protein ligase RNF125 protein (1-232AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO43476 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO43476 at dilution of 1:100. |
Background: | E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. |
Synonyms: | E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1), RNF125 |
UniProt Protein Function: | RNF125: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ligase Chromosomal Location of Human Ortholog: 18q12.1 Molecular Function:zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: protein ubiquitination; innate immune response; negative regulation of interferon type I production Disease: Tenorio Syndrome |
NCBI Summary: | This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q96EQ8 |
NCBI GenInfo Identifier: | 37595555 |
NCBI Gene ID: | 54941 |
NCBI Accession: | NP_060301 |
UniProt Related Accession: | Q96EQ8 |
Molecular Weight: | 26kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF125 |
NCBI Synonym Full Names: | ring finger protein 125 |
NCBI Official Symbol: | RNF125 |
NCBI Official Synonym Symbols: | TNORS; TRAC1; TRAC-1 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF125 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF125 |
UniProt Synonym Protein Names: | RING finger protein 125; T-cell RING activation protein 1 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF125 |
UniProt Entry Name: | RN125_HUMAN |
Antibodies |
Anti-RNF125 Antibody (CAB15165) |
Anti-RNF125 Antibody (CAB15166) |
Anti-RNF125 Antibody (CAB7982) |
RNF125 Antibody (PACO04664) |
RNF125 Antibody (PACO11865) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |