RGS20 Antibody (PACO44021)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44021
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RGS20 Antibody (PACO44021) |
Antibody SKU: | PACO44021 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Regulator of G-protein signaling 20 protein (1-241AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RGS20 antibody at 8µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44, 32, 22, 18, 26, 28 kDa. Observed band size: 44 kDa.. | |
Immunofluorescent analysis of A549 cells using PACO44021 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44021 at dilution of 1:100. |
Background: | Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-α and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-α activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. |
Synonyms: | Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1), RGS20, RGSZ1 ZGAP1 |
UniProt Protein Function: | RGS20: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs, misc.; GAPs Chromosomal Location of Human Ortholog: 8q11.23 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; GTPase activator activity Biological Process: regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity |
NCBI Summary: | The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
UniProt Code: | O76081 |
NCBI GenInfo Identifier: | 18266795 |
NCBI Gene ID: | 8601 |
NCBI Accession: | O76081.4 |
UniProt Secondary Accession: | O76081,Q96BG9, |
UniProt Related Accession: | O76081 |
Molecular Weight: | 27,060 Da |
NCBI Full Name: | Regulator of G-protein signaling 20 |
NCBI Synonym Full Names: | regulator of G-protein signaling 20 |
NCBI Official Symbol: | RGS20 |
NCBI Official Synonym Symbols: | RGSZ1; ZGAP1; gz-GAP; g(z)GAP |
NCBI Protein Information: | regulator of G-protein signaling 20; regulator of G-protein signaling Z1; regulator of G-protein signalling 20; gz-selective GTPase-activating protein; regulator of G-protein signaling 20 variant 2; regulator of Gz-selective protein signaling 1 |
UniProt Protein Name: | Regulator of G-protein signaling 20 |
UniProt Synonym Protein Names: | Gz-selective GTPase-activating protein; G(z)GAP; Gz-GAP; Regulator of G-protein signaling Z1; Regulator of Gz-selective protein signaling 1 |
Protein Family: | Regulator of G-protein signaling |
UniProt Gene Name: | RGS20 |
UniProt Entry Name: | RGS20_HUMAN |