RGS10 Antibody (PACO16974)
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주문- SKU:
- PACO16974
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RGS10 Antibody (PACO16974) |
Antibody SKU: | PACO16974 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human RGS10 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16974(RGS10 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G α subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go α and Gq α subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid, sequence termed the RGS domain. |
Synonyms: | regulator of G-protein signaling 10 |
UniProt Protein Function: | RGS10: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. |
UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 10q25 Cellular Component: cell soma; cytoplasm; dendritic spine; plasma membrane; nerve terminal; nucleus Molecular Function:GTPase activator activity Biological Process: positive regulation of GTPase activity |
NCBI Summary: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43665 |
NCBI GenInfo Identifier: | 52694755 |
NCBI Gene ID: | 6001 |
NCBI Accession: | NP_001005339.1 |
UniProt Secondary Accession: | O43665,Q6IAZ6, Q96GN0, A8K408, B1AMR8, |
UniProt Related Accession: | O43665 |
Molecular Weight: | 20 KD |
NCBI Full Name: | regulator of G-protein signaling 10 isoform a |
NCBI Synonym Full Names: | regulator of G-protein signaling 10 |
NCBI Official Symbol: | RGS10 |
NCBI Protein Information: | regulator of G-protein signaling 10; regulator of G-protein signalling 10 |
UniProt Protein Name: | Regulator of G-protein signaling 10 |
Protein Family: | Regulator of G-protein signaling |
UniProt Gene Name: | RGS10 |
UniProt Entry Name: | RGS10_HUMAN |
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Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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