RGMA Antibody (PACO38418)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO38418
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RGMA Antibody (PACO38418) |
Antibody SKU: | PACO38418 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Repulsive guidance molecule A protein (153-408AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. All lanes: RGMA antibody at 12µg/ml. Lane 1: Mouse brain tissue. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 50, 48, 51 kDa. Observed band size: 50 kDa. | |
Immunohistochemistry of paraffin-embedded human lung tissue using PACO38418 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human heart tissue using PACO38418 at dilution of 1:100. |
Background: | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. |
Synonyms: | Repulsive guidance molecule A (RGM domain family member A), RGMA, RGM |
NCBI Summary: | This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q96B86 |
NCBI GenInfo Identifier: | 296452979 |
NCBI Gene ID: | 56963 |
NCBI Accession: | Q96B86.3 |
UniProt Related Accession: | Q96B86 |
Molecular Weight: | 72.5 kDa |
NCBI Full Name: | Repulsive guidance molecule A |
NCBI Synonym Full Names: | repulsive guidance molecule BMP co-receptor a |
NCBI Official Symbol: | RGMA |
NCBI Official Synonym Symbols: | RGM |
NCBI Protein Information: | repulsive guidance molecule A |
UniProt Protein Name: | Repulsive guidance molecule A |
UniProt Synonym Protein Names: | RGM domain family member A |
Protein Family: | Repulsive guidance molecule |
UniProt Gene Name: | RGMA |
UniProt Entry Name: | RGMA_HUMAN |
Antibodies | ELISA Kits |
Anti-RGMA Antibody (CAB4878) | Human Repulsive guidance molecule A (RGMA) ELISA Kit |
RGMA Antibody (PACO11814) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |