RDM1 Antibody (PACO44023)
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주문- SKU:
- PACO44023
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RDM1 Antibody (PACO44023) |
Antibody SKU: | PACO44023 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human RAD52 motif-containing protein 1 protein (125-284AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RDM1 antibody at 4µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: MCF-7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32, 30, 16, 14, 29, 26, 9, 13, 19, 27 kDa. Observed band size: 32 kDa.. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44023 at dilution of 1:100. |
Background: | May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA. |
Synonyms: | RAD52 motif-containing protein 1 (RAD52 homolog B), RDM1, RAD52B |
UniProt Protein Function: | RDM1: May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA. 11 isoforms of the human protein are produced by alternative promoter. |
UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: Cajal body; PML body; cytoplasm; nucleolus Molecular Function:DNA binding; RNA binding; nucleotide binding Biological Process: DNA repair; DNA recombination |
NCBI Summary: | This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NG50 |
NCBI GenInfo Identifier: | 74762574 |
NCBI Gene ID: | 201299 |
NCBI Accession: | Q8NG50.1 |
UniProt Secondary Accession: | Q8NG50,A0JP55, A8MV46, A8MY68, A8MZ92, A8RCS5, A8RCT0 A8RCT5, A8RCT8, A8RCU3, A8RCU8, A8RCW0, |
UniProt Related Accession: | Q8NG50 |
Molecular Weight: | 284 |
NCBI Full Name: | RAD52 motif-containing protein 1 |
NCBI Synonym Full Names: | RAD52 motif containing 1 |
NCBI Official Symbol: | RDM1 |
NCBI Official Synonym Symbols: | RAD52B |
NCBI Protein Information: | RAD52 motif-containing protein 1; RAD52 motif 1; RAD52 homolog B |
UniProt Protein Name: | RAD52 motif-containing protein 1 |
UniProt Synonym Protein Names: | RAD52 homolog B |
Protein Family: | RAD52 motif-containing protein |
UniProt Gene Name: | RDM1 |
UniProt Entry Name: | RDM1_HUMAN |