RCAN1 Antibody (PACO06439)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO06439
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RCAN1 Antibody (PACO06439) |
Antibody SKU: | PACO06439 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from the C-terminal region of human DSCR 1. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of NIH-3T3 cells using DSCR 1 Polyclonal Antibody. | |
Western Blot analysis of HeLa cells using DSCR 1 Polyclonal Antibody. |
Synonyms: | RCAN1; ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1 |
UniProt Protein Function: | RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 21q22.12 Cellular Component: cytoplasm; nucleus Molecular Function:calcium-dependent protein serine/threonine phosphatase regulator activity; DNA binding; transcription factor activity Biological Process: blood circulation; central nervous system development; signal transduction |
NCBI Summary: | The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
UniProt Code: | P53805 |
NCBI GenInfo Identifier: | 215274235 |
NCBI Gene ID: | 1827 |
NCBI Accession: | P53805.4 |
UniProt Secondary Accession: | P53805,O00582, O00583, Q53XT0, Q6IBC6, Q7Z555, Q96R03 Q9BU69, Q9UF15, Q9UME4, D3DSF9, |
UniProt Related Accession: | P53805 |
Molecular Weight: | 13,291 Da |
NCBI Full Name: | Calcipressin-1 |
NCBI Synonym Full Names: | regulator of calcineurin 1 |
NCBI Official Symbol: | RCAN1 |
NCBI Official Synonym Symbols: | CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78 |
NCBI Protein Information: | calcipressin-1 |
UniProt Protein Name: | Calcipressin-1 |
UniProt Synonym Protein Names: | Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1 |
Protein Family: | Calcipressin |
UniProt Gene Name: | RCAN1 |
UniProt Entry Name: | RCAN1_HUMAN |