RASSF5 Antibody (PACO44523)
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주문- SKU:
- PACO44523
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RASSF5 Antibody (PACO44523) |
Antibody SKU: | PACO44523 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ras association domain-containing protein 5 protein (1-265AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RASSF5antibody at 5.46µg/ml. Lane 1: Thp-1 whole cell lysate. Lane 2: 293T whole cell lysate. Lane 3: Jurkat whole cell lysate. Lane 4: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48, 31, 38 kDa. Observed band size: 48 kDa.. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO44523 at dilution of 1:100. |
Background: | Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
Synonyms: | Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL), RASSF5, NORE1 RAPL |
UniProt Protein Function: | RASSF5: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Autophagy; Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor Chromosomal Location of Human Ortholog: 1q32.1 Molecular Function:protein binding |
NCBI Summary: | This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WWW0 |
NCBI GenInfo Identifier: | 74751587 |
NCBI Gene ID: | 83593 |
NCBI Accession: | Q8WWW0.1 |
UniProt Secondary Accession: | Q8WWW0,Q5SY32, Q8WWV9, Q8WXF4, Q9BT99, A8K1E6, |
UniProt Related Accession: | Q8WWW0 |
Molecular Weight: | 47kDa |
NCBI Full Name: | Ras association domain-containing protein 5 |
NCBI Synonym Full Names: | Ras association domain family member 5 |
NCBI Official Symbol: | RASSF5 |
NCBI Official Synonym Symbols: | RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3 |
NCBI Protein Information: | ras association domain-containing protein 5 |
UniProt Protein Name: | Ras association domain-containing protein 5 |
UniProt Synonym Protein Names: | New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; RAPL |
Protein Family: | Ras association domain-containing protein |
UniProt Gene Name: | RASSF5 |