RASSF2 Antibody (PACO62971)
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주문- SKU:
- PACO62971
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RASSF2 Antibody (PACO62971) |
Antibody SKU: | PACO62971 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IP:1:200-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ras association domain-containing protein 2 protein (69-326AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Raji whole cell lysate, Jurkat whole cell lysate, HL-60 whole cell lysate. All lanes: RASSF2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38, 18 kDa. Observed band size: 38 kDa. | |
Immunoprecipitating RASSF2 in Raji whole cell lysate. Lane 1: Rabbit control IgG instead of PACO62971 in Raji whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/50000). Lane 2: PACO62971 (5µg) + Raji whole cell lysate (0.5mg). Lane 3: Raji whole cell lysate (20µg). |
Background: | Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. |
Synonyms: | Ras association domain-containing protein 2, RASSF2, CENP-34 KIAA0168 |
UniProt Protein Function: | RASSF2: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Tumor suppressor Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytoplasm; nucleus; protein complex Molecular Function:protein binding; protein kinase activity Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of JNK cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase activity; protein stabilization |
NCBI Summary: | This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50749 |
NCBI GenInfo Identifier: | 1723118 |
NCBI Gene ID: | 9770 |
NCBI Accession: | P50749.1 |
UniProt Secondary Accession: | P50749,Q17S06, Q53HD0, Q6AHZ2, Q8IZA5, A6NIX9, A8K5Z3 |
UniProt Related Accession: | P50749 |
Molecular Weight: | 17,879 Da |
NCBI Full Name: | Ras association domain-containing protein 2 |
NCBI Synonym Full Names: | Ras association domain family member 2 |
NCBI Official Symbol: | RASSF2 |
NCBI Official Synonym Symbols: | CENP-34; RASFADIN |
NCBI Protein Information: | ras association domain-containing protein 2 |
UniProt Protein Name: | Ras association domain-containing protein 2 |
Protein Family: | Ras association domain-containing protein |
UniProt Gene Name: | RASSF2 |
UniProt Entry Name: | RASF2_HUMAN |