RAB35 Antibody (PACO17512)
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주문- SKU:
- PACO17512
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RAB35 Antibody (PACO17512) |
Antibody SKU: | PACO17512 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human RAB35 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17512(RAB35 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17512(RAB35 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. Rab35 plays an important role in insulin-stimulated GLUT4 translocation in adipocytes.It is the target of TBC1D10A–C and that the intracellular accumulation of endosomal vesicles and impairs exosome secretion were occured when inhibition of Rab35 function.The surface of oligodendroglia in a GTP-dependent manner was localized Rab35, it increases the density of vesicles, and may have a function in docking or tethering. |
Synonyms: | Ras-related protein Rab-35 |
UniProt Protein Function: | RAB35: In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Interacts with DENND1A and DENND1B in a nucleotide- dependent manner. The low binding to DENND1C is nucleotide- independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cell projection membrane; clathrin-coated endocytic vesicle; coated pit; endoplasmic reticulum membrane; endosome membrane; Golgi membrane; intercellular bridge; plasma membrane Molecular Function:GDP binding; GTP binding; GTPase activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding Biological Process: antigen processing and presentation; cytokinesis; endocytic recycling; endosome transport; ER to Golgi vesicle-mediated transport; neurite development; plasma membrane to endosome transport; protein localization |
UniProt Code: | Q15286 |
NCBI GenInfo Identifier: | 3024525 |
NCBI Gene ID: | 11021 |
NCBI Accession: | Q15286.1 |
UniProt Secondary Accession: | Q15286,B2R6E0, B4E390, |
UniProt Related Accession: | Q15286 |
Molecular Weight: | 17,058 Da |
NCBI Full Name: | Ras-related protein Rab-35 |
NCBI Synonym Full Names: | RAB35, member RAS oncogene family |
NCBI Official Symbol: | RAB35 |
NCBI Official Synonym Symbols: | RAY; H-ray; RAB1C |
NCBI Protein Information: | ras-related protein Rab-35 |
UniProt Protein Name: | Ras-related protein Rab-35 |
UniProt Synonym Protein Names: | GTP-binding protein RAY; Ras-related protein Rab-1C |
Protein Family: | Ras-related protein |
UniProt Gene Name: | RAB35 |
UniProt Entry Name: | RAB35_HUMAN |
Antibodies |
Anti-RAB35 Antibody (CAB8030) |
Anti-RAB35 Antibody (CAB17091) |
RAB35 Antibody (PACO01384) |
RAB35 Antibody (PACO11651) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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