QKI Antibody (PACO44410)
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주문- SKU:
- PACO44410
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | QKI Antibody (PACO44410) |
Antibody SKU: | PACO44410 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Protein quaking protein (1-341AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: QKI antibody at 1.92µg/ml. Lane 1: HL60 whole cell lysate. Lane 2: K562 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 38, 37, 36 kDa. Observed band size: 38, 70 kDa.. | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO44410 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44410 at dilution of 1:100. |
Background: | RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability. In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). |
Synonyms: | Protein quaking (Hqk) (HqkI), QKI, HKQ |
UniProt Protein Function: | RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. |
NCBI Summary: | The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q96PU8 |
NCBI GenInfo Identifier: | 74761039 |
NCBI Gene ID: | 9444 |
NCBI Accession: | Q96PU8.1 |
UniProt Secondary Accession: | Q96PU8,Q2I375, Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6 Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9, |
UniProt Related Accession: | Q96PU8 |
Molecular Weight: | 35,131 Da |
NCBI Full Name: | Protein quaking |
NCBI Synonym Full Names: | QKI, KH domain containing RNA binding |
NCBI Official Symbol: | QKI |
NCBI Official Synonym Symbols: | QK; Hqk; QK1; QK3; hqkI |
NCBI Protein Information: | protein quaking |
UniProt Protein Name: | Protein quaking |
Protein Family: | Protein quaking |
UniProt Gene Name: | QKI |
UniProt Entry Name: | QKI_HUMAN |