QARS Antibody (PACO43584)
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주문- SKU:
- PACO43584
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | QARS Antibody (PACO43584) |
Antibody SKU: | PACO43584 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Glutamine--tRNA ligase protein (1-250AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: Glutamine--tRNA ligase antibody at 2µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 88, 87 kDa. Observed band size: 88 kDa. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43584 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human colon tissue using PACO43584 at dilution of 1:100. |
Background: | Plays a critical role in brain development. |
Synonyms: | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS), QARS |
UniProt Protein Function: | QARS: catalyzes the formation of L-glutaminyl-tRNA. Belongs to the class-I aminoacyl-tRNA synthetase family. |
UniProt Protein Details: | Protein type:Ligase; EC 6.1.1.18; Mitochondrial; Translation Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: mitochondrial matrix; cytoplasm; cytosol Molecular Function:protein binding; glutamine-tRNA ligase activity; ATP binding Biological Process: tRNA aminoacylation for protein translation; glutaminyl-tRNA aminoacylation; gene expression; brain development Disease: Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy |
NCBI Summary: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
UniProt Code: | P47897 |
NCBI GenInfo Identifier: | 1351170 |
NCBI Gene ID: | 5859 |
NCBI Accession: | P47897.1 |
UniProt Secondary Accession: | P47897,B4DWJ2, |
UniProt Related Accession: | P47897 |
Molecular Weight: | 775 |
NCBI Full Name: | Glutamine--tRNA ligase |
NCBI Synonym Full Names: | glutaminyl-tRNA synthetase |
NCBI Official Symbol: | QARS |
NCBI Official Synonym Symbols: | GLNRS; MSCCA; PRO2195 |
NCBI Protein Information: | glutamine--tRNA ligase; glutamine-tRNA synthetase |
UniProt Protein Name: | Glutamine--tRNA ligase |
UniProt Synonym Protein Names: | Glutaminyl-tRNA synthetase; GlnRS |
UniProt Gene Name: | QARS |
UniProt Entry Name: | SYQ_HUMAN |