PVR Antibody (PACO43566)
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주문- SKU:
- PACO43566
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PVR Antibody (PACO43566) |
Antibody SKU: | PACO43566 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Poliovirus receptor protein (220-345AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: Poliovirus receptor antibody at 3µg/ml. Lane 1: Mouse gonad tissue. Lane 2: HepG2 whole cell lysate. Lane 3: K562 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 46, 41, 40, 43 kDa. Observed band size: 46 kDa. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43566 at dilution of 1:100. |
Background: | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-γ and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.2 Publications |
Synonyms: | Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155), PVR, PVS |
UniProt Protein Function: | PVR: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Belongs to the nectin family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Immunoglobulin superfamily Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: extracellular space; focal adhesion; cell surface; cytoplasm; integral to membrane; plasma membrane Molecular Function:viral receptor activity; protein binding; receptor activity; cell adhesion molecule binding Biological Process: intercellular junction assembly and maintenance; entry of virus into host cell; cell-cell adhesion; cell migration; regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; response to virus; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity |
NCBI Summary: | The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | P15151 |
NCBI GenInfo Identifier: | 1346922 |
NCBI Gene ID: | 5817 |
NCBI Accession: | P15151.2 |
UniProt Secondary Accession: | P15151,P15152, Q15267, Q15268, Q96BJ1, B4DTS9, |
UniProt Related Accession: | P15151 |
Molecular Weight: | Observed MW: 70kDaCalculated MW: 39kDa/40kDa/42kDa/45kDa |
NCBI Full Name: | Poliovirus receptor |
NCBI Synonym Full Names: | poliovirus receptor |
NCBI Official Symbol: | PVR |
NCBI Official Synonym Symbols: | PVS; HVED; CD155; NECL5; TAGE4; Necl-5 |
NCBI Protein Information: | poliovirus receptor; nectin-like protein 5 |
UniProt Protein Name: | Poliovirus receptor |
UniProt Synonym Protein Names: | Nectin-like protein 5; NECL-5; CD_antigen: CD155 |
Protein Family: | Poliovirus receptor |
UniProt Gene Name: | PVR |
UniProt Entry Name: | PVR_HUMAN |