PTPRE Antibody (PACO14947)
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주문- SKU:
- PACO14947
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PTPRE Antibody (PACO14947) |
Antibody SKU: | PACO14947 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:15-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human PTPRE |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14947(PTPRE Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14947(PTPRE Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. |
Synonyms: | protein tyrosine phosphatase, receptor type, E |
UniProt Protein Function: | PTPRE: a cytoplasmic and transmembrane receptor protein tyrosine phosphatase that regulates IL-10 and TNFA biosynthesis, myelination and cell-matrix adhesion, overexpression reduces tumor development |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 10q26 Cellular Component: cytoplasm; nucleus; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity Biological Process: negative regulation of insulin receptor signaling pathway; protein amino acid dephosphorylation |
NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015] |
UniProt Code: | P23469 |
NCBI GenInfo Identifier: | 126471 |
NCBI Gene ID: | 5791 |
NCBI Accession: | P23469.1 |
UniProt Secondary Accession: | P23469,Q13345, Q5VWH3, Q5VWH4, Q96KQ6, |
UniProt Related Accession: | P23469 |
Molecular Weight: | 71,382 Da |
NCBI Full Name: | Receptor-type tyrosine-protein phosphatase epsilon |
NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type E |
NCBI Official Symbol: | PTPRE |
NCBI Official Synonym Symbols: | PTPE; HPTPE; R-PTP-EPSILON |
NCBI Protein Information: | receptor-type tyrosine-protein phosphatase epsilon |
UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase epsilon |
Protein Family: | Receptor-type tyrosine-protein phosphatase |
UniProt Gene Name: | PTPRE |
UniProt Entry Name: | PTPRE_HUMAN |