PSTPIP1 Antibody (PACO44968)
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주문- SKU:
- PACO44968
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PSTPIP1 Antibody (PACO44968) |
Antibody SKU: | PACO44968 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: PSTPIP1 antibody at 3.99 µg/ml + Raw264.7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48, 46 kDa. Observed band size: 48 kDa.. |
Background: | Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. |
Synonyms: | Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP), PSTPIP1, CD2BP1 |
UniProt Protein Function: | PSTPIP1: an SH3-domain containing protein that may play a role in vesicle formation and transport. Interacts with PTP-PEST to inhibit WASp-driven actin polymerization and synapse formation. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 15q24.3 Cellular Component: membrane; lamellipodium; perinuclear region of cytoplasm; contractile ring; stress fiber; uropod; cytosol; cleavage furrow Molecular Function:protein binding; actin binding; protein phosphatase binding Biological Process: innate immune response; endocytosis; inflammatory response; signal transduction; cell adhesion Disease: Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne |
NCBI Summary: | The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43586 |
NCBI GenInfo Identifier: | 74739557 |
NCBI Gene ID: | 9051 |
NCBI Accession: | O43586.1 |
UniProt Secondary Accession: | O43586,O43585, O95657, B5BU74, B5BUK4, |
UniProt Related Accession: | O43586 |
Molecular Weight: | 416 |
NCBI Full Name: | Proline-serine-threonine phosphatase-interacting protein 1 |
NCBI Synonym Full Names: | proline-serine-threonine phosphatase interacting protein 1 |
NCBI Official Symbol: | PSTPIP1 |
NCBI Official Synonym Symbols: | H-PIP; PAPAS; CD2BP1; PSTPIP; CD2BP1L; CD2BP1S |
NCBI Protein Information: | proline-serine-threonine phosphatase-interacting protein 1; CD2-binding protein 1; CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; PEST phosphatase-interacting protein 1 |
UniProt Protein Name: | Proline-serine-threonine phosphatase-interacting protein 1 |
UniProt Synonym Protein Names: | CD2-binding protein 1; H-PIP |
Protein Family: | Proline-serine-threonine phosphatase-interacting protein |
UniProt Gene Name: | PSTPIP1 |
UniProt Entry Name: | PPIP1_HUMAN |