PRKX Antibody (PACO18643)
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주문- SKU:
- PACO18643
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PRKX Antibody (PACO18643) |
Antibody SKU: | PACO18643 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human PRKX |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18643(PRKX Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A549 cells, Jurkat cells, 293T cells, K562 cells, Primary antibody: PACO18643(PRKX Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18643(PRKX Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. |
Synonyms: | protein kinase, X-linked |
UniProt Protein Function: | PRKX: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. |
UniProt Protein Details: | Protein type:Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; PKA family Chromosomal Location of Human Ortholog: Xp22.3 Cellular Component: cytoplasm; nucleus Molecular Function:cAMP-dependent protein kinase activity; protein binding Biological Process: angiogenesis; cell adhesion; cell-substrate adhesion; endothelial cell migration; endothelial cell proliferation; myeloid cell differentiation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; regulation of cell adhesion; regulation of cell migration |
NCBI Summary: | This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010] |
UniProt Code: | P51817 |
NCBI GenInfo Identifier: | 1709648 |
NCBI Gene ID: | 5613 |
NCBI Accession: | P51817.1 |
UniProt Related Accession: | P51817 |
Molecular Weight: | 40,896 Da |
NCBI Full Name: | cAMP-dependent protein kinase catalytic subunit PRKX |
NCBI Synonym Full Names: | protein kinase, X-linked |
NCBI Official Symbol: | PRKX |
NCBI Official Synonym Symbols: | PKX1 |
NCBI Protein Information: | cAMP-dependent protein kinase catalytic subunit PRKX |
UniProt Protein Name: | cAMP-dependent protein kinase catalytic subunit PRKX |
UniProt Synonym Protein Names: | Protein kinase PKX1 |
Protein Family: | cAMP-dependent protein kinase |
UniProt Gene Name: | PRKX |
UniProt Entry Name: | PRKX_HUMAN |