PRKG2 Antibody (PACO18631)
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주문- SKU:
- PACO18631
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PRKG2 Antibody (PACO18631) |
Antibody SKU: | PACO18631 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human PRKG2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18631(PRKG2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Mouse brain tissue, Mouse lung tissue, Primary antibody: PACO18631(PRKG2 Antibody) at dilution 1/160, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18631(PRKG2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | cGKII (cGMP-dependent protein kinase type II) is a major receptor of intracellular cGMP and mediates a plethora of physiological responses. cGKII contains a conserved leucine zipper motif at the amino-terminus. It is expressed in small intestine, colon, prostate, and human brain tissues, and the cGKII gene maps to chromosome 4q13.1-q21.1. cGKII has been shown to regulate the ion transport system in the intestine. Myristoylation of the penultimate glycine in cGKII appears to be essential for directing cGKII to the membrane, since cGKII is devoid of any hydrophobic transmembrane domains. The translocation of cGKII from the cytosol to the membrane allows it to function properly in regulating intestinal ion transport. |
Synonyms: | protein kinase, cGMP-dependent, type II |
UniProt Protein Function: | PKG2: an AGC kinase of the PKG family. Type II cGMP-dependent protein kinase is expressed at high levels in brain, lung and intestinal mucosa. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, AGC; EC 2.7.11.12; Protein kinase, Ser/Thr (non-receptor); AGC group; PKG family Chromosomal Location of Human Ortholog: 4q13.1-q21.1 Cellular Component: apical plasma membrane; cytosol; nuclear membrane Molecular Function:ATP binding; cGMP binding; cGMP-dependent protein kinase activity; protein homodimerization activity; protein kinase activity Biological Process: blood coagulation; circadian regulation of gene expression; nitric oxide metabolic process; protein amino acid phosphorylation; regulation of nitric-oxide synthase activity; signal transduction |
NCBI Summary: | This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q13237 |
NCBI GenInfo Identifier: | 6226833 |
NCBI Gene ID: | 5593 |
NCBI Accession: | Q13237.1 |
UniProt Secondary Accession: | Q13237,O00125, O60916, B4DMX3, E7EPE6, |
UniProt Related Accession: | Q13237 |
Molecular Weight: | 84,398 Da |
NCBI Full Name: | cGMP-dependent protein kinase 2 |
NCBI Synonym Full Names: | protein kinase, cGMP-dependent, type II |
NCBI Official Symbol: | PRKG2 |
NCBI Official Synonym Symbols: | cGK2; cGKII; PRKGR2 |
NCBI Protein Information: | cGMP-dependent protein kinase 2 |
UniProt Protein Name: | cGMP-dependent protein kinase 2 |
UniProt Synonym Protein Names: | cGMP-dependent protein kinase II; cGKII |
Protein Family: | cGMP-dependent protein kinase |
UniProt Gene Name: | PRKG2 |
UniProt Entry Name: | KGP2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |