UniProt Protein Function: | PRDX6: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Belongs to the AhpC/TSA family. Rehydrin subfamily. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - phenylalanine; Oxidoreductase; Energy Metabolism - methane; EC 1.11.1.9; EC 1.11.1.15; Phospholipase Chromosomal Location of Human Ortholog: 1q25.1 Cellular Component: extracellular space; membrane; lysosome; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol Molecular Function:antioxidant activity; phospholipase A2 activity; protein binding; peroxiredoxin activity; glutathione peroxidase activity Biological Process: response to reactive oxygen species; phospholipid catabolic process; hydrogen peroxide catabolic process; response to oxidative stress |
NCBI Summary: | The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30041 |
NCBI GenInfo Identifier: | 1718024 |
NCBI Gene ID: | 9588 |
NCBI Accession: | P30041.3 |
UniProt Secondary Accession: | P30041,P32077, Q5TAH4, Q5ZEZ8, A8JZY7, |
UniProt Related Accession: | P30041 |
Molecular Weight: | Observed: 27kDaCalculated: 25kDa |
NCBI Full Name: | Peroxiredoxin-6 |
NCBI Synonym Full Names: | peroxiredoxin 6 |
NCBI Official Symbol: | PRDX6 |
NCBI Official Synonym Symbols: | PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m |
NCBI Protein Information: | peroxiredoxin-6; 1-Cys PRX; 24 kDa protein; 1-Cys peroxiredoxin; antioxidant protein 2; liver 2D page spot 40; red blood cells page spot 12; non-selenium glutathione peroxidase; acidic calcium-independent phospholipase A2; epididymis secretory sperm binding protein Li 128m |
UniProt Protein Name: | Peroxiredoxin-6 |
UniProt Synonym Protein Names: | 1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2 (EC:3.1.1.-); aiPLA2; Antioxidant protein 2; Liver 2D page spot 40; Non-selenium glutathione peroxidase (EC:1.11.1.9); NSGPx; Red blood cells page spot 12 |
Protein Family: | Peroxiredoxin |
UniProt Gene Name: | PRDX6 |
UniProt Entry Name: | PRDX6_HUMAN |