PRDX1 Antibody (PACO18366)
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주문- SKU:
- PACO18366
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PRDX1 Antibody (PACO18366) |
Antibody SKU: | PACO18366 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human PRDX1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18366(PRDX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Mouse liver tissue, NIH/3T3 cells, RAW264.7 cells, 293T cells, K562 cells, Jurkat cells, hela cells, Primary antibody: PACO18366(PRDX1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18366(PRDX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. |
Synonyms: | peroxiredoxin 1 |
UniProt Protein Function: | PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Oxidoreductase; EC 1.11.1.15 Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: peroxisomal matrix; extracellular space; mitochondrial matrix; cytoplasm; nucleolus; melanosome; nucleus; cytosol Molecular Function:protein binding; peroxidase activity; protein homodimerization activity; thioredoxin peroxidase activity; heme binding Biological Process: cell proliferation; retinal homeostasis; erythrocyte homeostasis; regulation of stress-activated MAPK cascade; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; natural killer cell mediated cytotoxicity; skeletal development; regulation of NF-kappaB import into nucleus |
NCBI Summary: | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011] |
UniProt Code: | Q06830 |
NCBI GenInfo Identifier: | 548453 |
NCBI Gene ID: | 5052 |
NCBI Accession: | Q06830.1 |
UniProt Related Accession: | Q06830 |
Molecular Weight: | |
NCBI Full Name: | Peroxiredoxin-1 |
NCBI Synonym Full Names: | peroxiredoxin 1 |
NCBI Official Symbol: | PRDX1 |
NCBI Official Synonym Symbols: | PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A |
NCBI Protein Information: | peroxiredoxin-1 |
UniProt Protein Name: | Peroxiredoxin-1 |
UniProt Synonym Protein Names: | Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2 |
UniProt Gene Name: | PRDX1 |
UniProt Entry Name: | PRDX1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |