PRCP Antibody (PACO14907)
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주문- SKU:
- PACO14907
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PRCP Antibody (PACO14907) |
Antibody SKU: | PACO14907 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human PRCP |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14907(PRCP Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-3: SKOV3 cells, A549 cells, human liver cancer tissue, Primary antibody: PACO14907(PRCP Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14907(PRCP Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acid, linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acid, c pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Synonyms: | Prolylcarboxypeptidase (angiotensinase C) |
UniProt Protein Function: | PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family. |
UniProt Protein Details: | Protein type:EC 3.4.16.2; Protease Chromosomal Location of Human Ortholog: 11q14 Cellular Component: lysosome; plasma membrane Molecular Function:serine carboxypeptidase activity; protein binding Biological Process: plasma kallikrein-kinin cascade; negative regulation of systemic arterial blood pressure; regulation of blood vessel endothelial cell migration; glucose homeostasis; proteolysis; blood coagulation; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway |
NCBI Summary: | This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | P42785 |
NCBI GenInfo Identifier: | 1172047 |
NCBI Gene ID: | 5547 |
NCBI Accession: | P42785.1 |
UniProt Related Accession: | P42785 |
Molecular Weight: | |
NCBI Full Name: | Lysosomal Pro-X carboxypeptidase |
NCBI Synonym Full Names: | prolylcarboxypeptidase |
NCBI Official Symbol: | PRCP |
NCBI Official Synonym Symbols: | PCP; HUMPCP |
NCBI Protein Information: | lysosomal Pro-X carboxypeptidase |
UniProt Protein Name: | Lysosomal Pro-X carboxypeptidase |
UniProt Synonym Protein Names: | Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP |
Protein Family: | Paracaspase |
UniProt Gene Name: | PRCP |
UniProt Entry Name: | PCP_HUMAN |
Antibodies | ELISA Kits |
Anti-PRCP Antibody (CAB4040) | Human Prolylcarboxypeptidase / PRCP ELISA Kit |
PRCP Antibody (PACO11449) | Human PRCP (Prolylcarboxypeptidase) ELISA Kit (HUES02338) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |