PRC1 Antibody (PACO16894)
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주문- SKU:
- PACO16894
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PRC1 Antibody (PACO16894) |
Antibody SKU: | PACO16894 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human PRC1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16894(PRC1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. |
Synonyms: | protein regulator of cytokinesis 1 |
UniProt Protein Function: | PRC1: translocates to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. Acts as a microtubule-binding and bundling protein both in vivo and vitro. Interacts with the C-terminal Rho-GAP domain and the basic region of MgcRacGAP. The interaction with MgcRacGAP inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: nucleoplasm; microtubule cytoskeleton; spindle pole; spindle microtubule; cytoplasm; plasma membrane; spindle; nucleus Molecular Function:identical protein binding; protein binding; kinesin binding; microtubule binding; protein kinase binding Biological Process: mitotic spindle elongation; cytokinesis |
NCBI Summary: | This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] |
UniProt Code: | O43663 |
NCBI GenInfo Identifier: | 215273870 |
NCBI Gene ID: | 9055 |
NCBI Accession: | O43663.2 |
UniProt Related Accession: | O43663 |
Molecular Weight: | 61kDa; 66kDa; 70kDa; 71kDa |
NCBI Full Name: | Protein regulator of cytokinesis 1 |
NCBI Synonym Full Names: | protein regulator of cytokinesis 1 |
NCBI Official Symbol: | PRC1 |
NCBI Official Synonym Symbols: | ASE1 |
NCBI Protein Information: | protein regulator of cytokinesis 1 |
UniProt Protein Name: | Protein regulator of cytokinesis 1 |
Protein Family: | Protein regulator of cytokinesis |
UniProt Gene Name: | PRC1 |
UniProt Entry Name: | PRC1_HUMAN |
Antibodies |
Anti-PRC1 Antibody (CAB7029) |
PRC1 Antibody (PACO07327) |
Phospho-PRC1 (Thr481) Antibody (PACO07328) |
PRC1 Antibody (PACO11447) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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