PPP1R8 Antibody (PACO44921)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44921
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PPP1R8 Antibody (PACO44921) |
Antibody SKU: | PACO44921 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Nuclear inhibitor of protein phosphatase 1 protein (1-209AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: PPP1R8 antibody at 4.73µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: HL60 whole cell lysate. Lane 3: HepG2 whole cell lysate. Lane 4: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 39, 23, 14 kDa. Observed band size: 39 kDa.. | |
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO44921 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44921 at dilution of 1:100. |
Background: | Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. |
Synonyms: | Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)], PPP1R8, ARD1 NIPP1 |
UniProt Protein Function: | NIPP-1: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Inhibitor; Protein phosphatase, regulatory subunit; Ribonuclease; EC 3.1.4.-; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: nucleoplasm; spliceosome; cytoplasm; nuclear speck; nucleus Molecular Function:protein binding; ribonuclease E activity; DNA binding; protein phosphatase type 1 regulator activity; RNA binding; endonuclease activity; type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA splicing; RNA catabolic process; negative regulation of catalytic activity; mRNA processing |
NCBI Summary: | This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12972 |
NCBI GenInfo Identifier: | 19863082 |
NCBI Gene ID: | 5511 |
NCBI Accession: | Q12972.2 |
UniProt Secondary Accession: | Q12972,Q5TEJ2, Q5TEJ4, Q5TIF2, Q6PKF6, Q9UBH1, Q9UBZ0 |
UniProt Related Accession: | Q12972 |
Molecular Weight: | 351 |
NCBI Full Name: | Nuclear inhibitor of protein phosphatase 1 |
NCBI Synonym Full Names: | protein phosphatase 1, regulatory subunit 8 |
NCBI Official Symbol: | PPP1R8 |
NCBI Official Synonym Symbols: | ARD1; ARD-1; NIPP1; NIPP-1; PRO2047 |
NCBI Protein Information: | nuclear inhibitor of protein phosphatase 1; RNase E; activator of RNA decay; nuclear subunit of PP-1; protein phosphatase 1 regulatory subunit 8; nuclear inhibitor of protein phosphatase-1 alpha; protein phosphatase 1, regulatory (inhibitor) subunit 8 |
UniProt Protein Name: | Nuclear inhibitor of protein phosphatase 1 |
UniProt Synonym Protein Names: | Protein phosphatase 1 regulatory inhibitor subunit 8Including the following 1 domains:Activator of RNA decay (EC:3.1.4.-)Alternative name(s):ARD-1 |
Protein Family: | Nuclear inhibitor of protein phosphatase |
UniProt Gene Name: | PPP1R8 |
UniProt Entry Name: | PP1R8_HUMAN |