PPP1R14A Antibody (PACO39530)
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주문- SKU:
- PACO39530
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PPP1R14A Antibody (PACO39530) |
Antibody SKU: | PACO39530 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Protein phosphatase 1 regulatory subunit 14A protein (1-147AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO39530 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39530 at dilution of 1:100. |
Background: | Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. |
Synonyms: | Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17), PPP1R14A, CPI17 PPP1INL |
UniProt Protein Function: | PPP1R14A: a phosphorylation-dependent inhibitory subunit of protein phosphatase 1 (PP-1A). Phosphorylation by PKC regulates its binding to PP-1A. Acts co-operatively to inhibit myosin light chain phosphatase (MLCP) activity. Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2 ) concentration. Involved in the regulation of cell morphology, re-organisation of microfilaments, and cell spreading. Also expressed in human platelets and in brain where it may play a role in cerebellar long-term synaptic depression. Phosphorylation by ILK or Rho kinase enhances its ability to inhibit PP-1A. |
UniProt Protein Details: | Protein type:Inhibitor; Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cytosol Molecular Function:protein phosphatase inhibitor activity Biological Process: negative regulation of catalytic activity; regulation of phosphorylation; small GTPase mediated signal transduction |
NCBI Summary: | The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q96A00 |
NCBI GenInfo Identifier: | 55583974 |
NCBI Gene ID: | 94274 |
NCBI Accession: | Q96A00.1 |
UniProt Secondary Accession: | Q96A00,Q7Z4X7, Q96S54, |
UniProt Related Accession: | Q96A00 |
Molecular Weight: | 13,480 Da |
NCBI Full Name: | Protein phosphatase 1 regulatory subunit 14A |
NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 14A |
NCBI Official Symbol: | PPP1R14A |
NCBI Official Synonym Symbols: | CPI17; CPI-17; PPP1INL |
NCBI Protein Information: | protein phosphatase 1 regulatory subunit 14A |
UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 14A |
UniProt Synonym Protein Names: | 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17 |
UniProt Gene Name: | PPP1R14A |
UniProt Entry Name: | PP14A_HUMAN |
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