PPM1F Antibody (PACO20268)
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주문- SKU:
- PACO20268
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PPM1F Antibody (PACO20268) |
Antibody SKU: | PACO20268 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human PPM1F |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-2: Human fetal liver tissue, K562 cells, Primary antibody: PACO20268(PPM1F Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
Background: | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II γ (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. |
Synonyms: | protein phosphatase, Mg2+/Mn2+ dependent, 1F |
UniProt Protein Function: | PPM1F: a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members can be negative regulators of cell stress response pathways. Interact with PAK-interacting exchange factor beta (ARHGEF7), blocking the effects PAK1, a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CaMK2-gamma) is one of the substrates of this phosphatase. Promotes apoptosis. |
UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.16; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 22q11.22 Cellular Component: cytosol; protein complex Molecular Function:calmodulin-dependent protein phosphatase activity; phosphoric monoester hydrolase activity; protein binding; protein serine/threonine phosphatase activity Biological Process: negative regulation of peptidyl-serine phosphorylation; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity; positive regulation of chemotaxis; positive regulation of focal adhesion formation; positive regulation of growth; positive regulation of stress fiber formation |
NCBI Summary: | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49593 |
NCBI GenInfo Identifier: | 24638458 |
NCBI Gene ID: | 9647 |
NCBI Accession: | P49593.3 |
UniProt Secondary Accession: | P49593,Q96PM2, A8K6G3, B7Z2C3, |
UniProt Related Accession: | P49593 |
Molecular Weight: | 38,518 Da |
NCBI Full Name: | Protein phosphatase 1F |
NCBI Synonym Full Names: | protein phosphatase, Mg2+/Mn2+ dependent 1F |
NCBI Official Symbol: | PPM1F |
NCBI Official Synonym Symbols: | CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase |
NCBI Protein Information: | protein phosphatase 1F |
UniProt Protein Name: | Protein phosphatase 1F |
UniProt Synonym Protein Names: | Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; Partner of PIX 2; Protein fem-2 homolog; hFem-2 |
Protein Family: | Protein phosphatase |
UniProt Gene Name: | PPM1F |
UniProt Entry Name: | PPM1F_HUMAN |