POU2AF1 Antibody (PACO17643)
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주문- SKU:
- PACO17643
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | POU2AF1 Antibody (PACO17643) |
Antibody SKU: | PACO17643 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human POU2AF1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17643(POU2AF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17643(POU2AF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene. POU2AF1 has been shown to interact with POU2F1 and SIAH1. POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It encourages the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is necessary for the response of B-cells to antigens and required for the formation of germinal centers. |
Synonyms: | POU class 2 associating factor 1 |
UniProt Protein Function: | POU2AF1: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6. Belongs to the POU2AF1 family. |
UniProt Protein Details: | Protein type:Oncoprotein; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 11q23.1 Cellular Component: nucleus Molecular Function:protein binding; DNA binding; transcription coactivator activity; transcription cofactor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; humoral immune response |
UniProt Code: | Q16633 |
NCBI GenInfo Identifier: | 2833276 |
NCBI Gene ID: | 5450 |
NCBI Accession: | Q16633.1 |
UniProt Secondary Accession: | Q16633,Q14983, B2R8Z9, |
UniProt Related Accession: | Q16633,AAB34937 |
Molecular Weight: | 256 |
NCBI Full Name: | POU domain class 2-associating factor 1 |
NCBI Synonym Full Names: | POU class 2 associating factor 1 |
NCBI Official Symbol: | POU2AF1 |
NCBI Official Synonym Symbols: | BOB1; OBF1; OCAB; OBF-1 |
NCBI Protein Information: | POU domain class 2-associating factor 1; BOB-1; OCA-B; OCT-binding factor 1; B-cell-specific coactivator OBF-1; POU domain, class 2, associating factor 1 |
UniProt Protein Name: | POU domain class 2-associating factor 1 |
UniProt Synonym Protein Names: | B-cell-specific coactivator OBF-1; BOB-1; OCA-B; OCT-binding factor 1 |
Protein Family: | POU domain class 2-associating factor |
UniProt Gene Name: | POU2AF1 |
UniProt Entry Name: | OBF1_HUMAN |