POP1 Antibody (PACO11371)
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주문- SKU:
- PACO11371
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | POP1 Antibody (PACO11371) |
Antibody SKU: | PACO11371 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human POP1 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae);POP1;KIAA0061;MGC17365 ; |
UniProt Protein Function: | POP1: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. Defects in POP1 may be the cause of a severe skeletal dysplasia reminiscent of anauxetic dysplasia. Affected individuals show severe growth retardation of prenatal onset, a bone dysplasia affecting the epiphyses and metaphyses of the long bones particularly in the lower limbs, and abnormalities of the spine including irregularly shaped vertebral bodies and marked cervical spine instability. |
UniProt Protein Details: | Protein type:Ribonuclease; EC 3.1.26.5; Nucleolus; RNA processing Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: nucleolar ribonuclease P complex; extracellular space; ribonuclease MRP complex Molecular Function:protein binding; ribonuclease MRP activity; ribonuclease P activity Biological Process: RNA processing; tRNA 5'-leader removal; tRNA catabolic process |
NCBI Summary: | This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009] |
UniProt Code: | Q99575 |
NCBI GenInfo Identifier: | 13124451 |
NCBI Gene ID: | 10940 |
NCBI Accession: | Q99575.2 |
UniProt Secondary Accession: | Q99575,Q15037, A8K5W9, |
UniProt Related Accession: | Q99575 |
Molecular Weight: | 1024 |
NCBI Full Name: | Ribonucleases P/MRP protein subunit POP1 |
NCBI Synonym Full Names: | processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) |
NCBI Official Symbol: | POP1 |
NCBI Protein Information: | ribonucleases P/MRP protein subunit POP1; hPOP1; processing of precursors 1 |
UniProt Protein Name: | Ribonucleases P/MRP protein subunit POP1 |
Protein Family: | Ribonucleases P/MRP protein |
UniProt Gene Name: | POP1 |
UniProt Entry Name: | POP1_HUMAN |