PNMA1 Antibody (PACO11327)
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주문- SKU:
- PACO11327
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PNMA1 Antibody (PACO11327) |
Antibody SKU: | PACO11327 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human PNMA1 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | paraneoplastic antigen MA1;PNMA1;MA1 ; |
UniProt Protein Function: | PNMA1: Belongs to the PNMA family |
UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: focal adhesion; cytoplasm; nucleolus Molecular Function:protein binding Biological Process: inflammatory response to antigenic stimulus; positive regulation of apoptosis |
NCBI Summary: | The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies.[supplied by OMIM, May 2010] |
UniProt Code: | Q8ND90 |
NCBI GenInfo Identifier: | 52486265 |
NCBI Gene ID: | 9240 |
NCBI Accession: | NP_006020.4 |
UniProt Secondary Accession: | Q8ND90,Q8C1C8, Q8VHZ4, |
UniProt Related Accession: | Q8ND90 |
Molecular Weight: | 39,761 Da |
NCBI Full Name: | paraneoplastic antigen Ma1 |
NCBI Synonym Full Names: | paraneoplastic Ma antigen 1 |
NCBI Official Symbol: | PNMA1 |
NCBI Official Synonym Symbols: | MA1 |
NCBI Protein Information: | paraneoplastic antigen Ma1; 37 kDa neuronal protein; paraneoplastic neuronal antigen MA1; neuron- and testis-specific protein 1 |
UniProt Protein Name: | Paraneoplastic antigen Ma1 |
UniProt Synonym Protein Names: | 37 kDa neuronal protein; Neuron- and testis-specific protein 1 |
UniProt Gene Name: | PNMA1 |
UniProt Entry Name: | PNMA1_HUMAN |