PMAIP1 Antibody (PACO46114)
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주문- SKU:
- PACO46114
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PMAIP1 Antibody (PACO46114) |
Antibody SKU: | PACO46114 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Phorbol-12-myristate-13-acetate-induced protein 1 protein (1-136AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human heart tissue using PACO46114 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO46114 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO46114 at dilution of 1:100. |
Background: | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
Synonyms: | Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa), PMAIP1, NOXA |
UniProt Protein Function: | NOXA: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Interacts with MCL1, BCL2A1 and BAX. Up-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. Highly expressed in adult T-cell leukemia cell line. Belongs to the PMAIP1 family. |
UniProt Protein Details: | Protein type:Apoptosis; Mitochondrial Chromosomal Location of Human Ortholog: 18q21.32 Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion; nucleus Molecular Function:protein binding Biological Process: apoptosis; cellular response to glucose starvation; defense response to virus; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein oligomerization; proteasomal protein catabolic process; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of apoptosis; regulation of mitochondrial membrane permeability; response to dsRNA; T cell homeostasis |
UniProt Code: | Q13794 |
NCBI GenInfo Identifier: | 6919841 |
NCBI Gene ID: | 5366 |
NCBI Accession: | Q13794.1 |
UniProt Secondary Accession: | Q13794,Q8N589, B2R4T7, |
UniProt Related Accession: | Q13794 |
Molecular Weight: | 6kDa |
NCBI Full Name: | Phorbol-12-myristate-13-acetate-induced protein 1 |
NCBI Synonym Full Names: | phorbol-12-myristate-13-acetate-induced protein 1 |
NCBI Official Symbol: | PMAIP1 |
NCBI Official Synonym Symbols: | APR; NOXA |
NCBI Protein Information: | phorbol-12-myristate-13-acetate-induced protein 1 |
UniProt Protein Name: | Phorbol-12-myristate-13-acetate-induced protein 1 |
UniProt Synonym Protein Names: | Immediate-early-response protein APR; Protein Noxa |
Protein Family: | Phorbol-12-myristate-13-acetate-induced protein |
UniProt Gene Name: | PMAIP1 |
Antibodies | ELISA Kits |
Anti-PMAIP1 Antibody (CAB9801) | Human PMAIP1 / NOXA ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |