PLXNA3 Antibody (PACO20247)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO20247
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PLXNA3 Antibody (PACO20247) |
Antibody SKU: | PACO20247 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human PLXNA3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20247(PLXNA3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. |
Synonyms: | plexin A3 |
UniProt Protein Function: | PLXNA3: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cell junction; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane Molecular Function:protein binding; semaphorin receptor activity Biological Process: branchiomotor neuron axon guidance; multicellular organismal development; regulation of axon extension involved in axon guidance; regulation of cell migration |
NCBI Summary: | This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013] |
UniProt Code: | P51805 |
NCBI GenInfo Identifier: | 533112479 |
NCBI Gene ID: | 55558 |
NCBI Accession: | NP_059984 |
UniProt Secondary Accession: | P51805,Q5HY36, |
UniProt Related Accession: | P51805 |
Molecular Weight: | |
NCBI Full Name: | plexin-A3 |
NCBI Synonym Full Names: | plexin A3 |
NCBI Official Symbol: | PLXNA3 |
NCBI Official Synonym Symbols: | 6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE |
NCBI Protein Information: | plexin-A3 |
UniProt Protein Name: | Plexin-A3 |
UniProt Synonym Protein Names: | Plexin-4; Semaphorin receptor SEX |
Protein Family: | Plexin |
UniProt Gene Name: | PLXNA3 |
UniProt Entry Name: | PLXA3_HUMAN |