PLP1 Antibody (PACO29010)
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주문- SKU:
- PACO29010
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PLP1 Antibody (PACO29010) |
Antibody SKU: | PACO29010 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Myelin proteolipid protein (143-197AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: PLP1 antibody at 4µg/ml Lane 1: Hela whole cell lysate Lane 2: HL60 whole cell lysate Lane 3: K562 whole cell lysate Lane 4: THP-1 whole cell lysate Lane 5: U937 whole cell lysate Lane 6: A549 whole cell lysate Lane 7: Caco-2 whole cell lysate Lane 8: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31, 27 kDa Observed band size: 31 kDa . | |
Immunofluorescent analysis of Hela cells using PACO29010 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO29010 at dilution of 1:100. |
Background: | This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. |
Synonyms: | Myelin proteolipid protein (PLP) (Lipophilin), PLP1, PLP |
UniProt Protein Function: | PLP1: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1); also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay. Defects in PLP1 are the cause of spastic paraplegia X- linked type 2 (SPG2). SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy. Belongs to the myelin proteolipid protein family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq22.2 Cellular Component: integral component of membrane; myelin sheath; plasma membrane Molecular Function:protein binding; structural constituent of myelin sheath; structural molecule activity Biological Process: astrocyte development; axon ensheathment; cell maturation; inflammatory response; integrin-mediated signaling pathway; long-chain fatty acid biosynthetic process; myelination in the central nervous system; substantia nigra development; synaptic transmission Disease: Pelizaeus-merzbacher Disease; Spastic Paraplegia 2, X-linked |
NCBI Summary: | This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015] |
UniProt Code: | P60201 |
NCBI GenInfo Identifier: | 41349499 |
NCBI Gene ID: | 5354 |
NCBI Accession: | NP_000524.3 |
UniProt Secondary Accession: | P60201,P04400, P06905, Q502Y1, Q6FHZ6, |
UniProt Related Accession: | P60201 |
Molecular Weight: | 26,274 Da |
NCBI Full Name: | myelin proteolipid protein isoform 1 |
NCBI Synonym Full Names: | proteolipid protein 1 |
NCBI Official Symbol: | PLP1 |
NCBI Official Synonym Symbols: | PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20 |
NCBI Protein Information: | myelin proteolipid protein |
UniProt Protein Name: | Myelin proteolipid protein |
UniProt Synonym Protein Names: | Lipophilin |
Protein Family: | Proteolipid protein |
UniProt Gene Name: | PLP1 |
Antibodies | ELISA Kits |
Anti-PLP1 Antibody (CAB14251) | Human Myelin proteolipid protein (PLP1) ELISA Kit |
Anti-PLP1 Antibody (CAB20009) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |