PLCD4 Antibody (PACO45032)
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주문- SKU:
- PACO45032
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PLCD4 Antibody (PACO45032) |
Antibody SKU: | PACO45032 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 protein (1-290AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45032 at dilution of 1:100. | |
Immunofluorescent analysis of A549 cells using PACO45032 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. |
Synonyms: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4), PLCD4 |
UniProt Protein Function: | PLCD4: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nuclear membrane; endoplasmic reticulum; cytoplasm; plasma membrane Molecular Function:signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity Biological Process: acrosome reaction; phosphatidylinositol metabolic process; lipid catabolic process |
NCBI Summary: | This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011] |
UniProt Code: | Q9BRC7 |
NCBI GenInfo Identifier: | 74732863 |
NCBI Gene ID: | 84812 |
NCBI Accession: | Q9BRC7.1 |
UniProt Secondary Accession: | Q9BRC7,Q53FS8, |
UniProt Related Accession: | Q9BRC7 |
Molecular Weight: | 31,448 Da |
NCBI Full Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
NCBI Synonym Full Names: | phospholipase C, delta 4 |
NCBI Official Symbol: | PLCD4 |
NCBI Protein Information: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; PLC delta4; phosphoinositide phospholipase C-delta-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 |
UniProt Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
UniProt Synonym Protein Names: | Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4 |
Protein Family: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
UniProt Gene Name: | PLCD4 |
UniProt Entry Name: | PLCD4_HUMAN |