UniProt Protein Function: | uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 19q13 Cellular Component: endoplasmic reticulum membrane; focal adhesion; extrinsic to membrane; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; integral to membrane Molecular Function:protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor activity; receptor binding Biological Process: fibrinolysis; cellular protein metabolic process; regulation of proteolysis; attachment of GPI anchor to protein; C-terminal protein lipidation; post-translational protein modification; cell motility; chemotaxis; signal transduction; blood coagulation |
NCBI Summary: | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q03405 |
NCBI GenInfo Identifier: | 465003 |
NCBI Gene ID: | 5329 |
NCBI Accession: | Q03405.1 |
UniProt Secondary Accession: | Q03405,Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8 Q9UD69, Q9UEA6, Q9UM92, Q9UMV0, A8K409, |
UniProt Related Accession: | Q03405 |
Molecular Weight: | 32,016 Da |
NCBI Full Name: | Urokinase plasminogen activator surface receptor |
NCBI Synonym Full Names: | plasminogen activator, urokinase receptor |
NCBI Official Symbol: | PLAUR |
NCBI Official Synonym Symbols: | CD87; UPAR; URKR; U-PAR |
NCBI Protein Information: | urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor |
UniProt Protein Name: | Urokinase plasminogen activator surface receptor |
UniProt Synonym Protein Names: | Monocyte activation antigen Mo3; CD_antigen: CD87 |
Protein Family: | Urokinase plasminogen activator surface receptor |
UniProt Gene Name: | PLAUR |
UniProt Entry Name: | UPAR_HUMAN |