PIWIL3 Antibody (PACO19169)
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주문- SKU:
- PACO19169
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PIWIL3 Antibody (PACO19169) |
Antibody SKU: | PACO19169 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human PIWIL3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19169(PIWIL3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: PACO19169(PIWIL3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19169(PIWIL3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | piwi-like RNA-mediated gene silencing 3 |
UniProt Protein Function: | HTRA3: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. Belongs to the peptidase S1B family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.21.-; Secreted, signal peptide; Protease; Secreted Chromosomal Location of Human Ortholog: 4p16.1 Cellular Component: extracellular region Molecular Function:insulin-like growth factor binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity Biological Process: regulation of cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis; negative regulation of BMP signaling pathway |
NCBI Summary: | This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q7Z3Z3 |
NCBI GenInfo Identifier: | 153792298 |
NCBI Gene ID: | 440822 |
NCBI Accession: | NP_001008496 |
UniProt Related Accession: | Q7Z3Z3 |
Molecular Weight: | 101,089 Da |
NCBI Full Name: | piwi-like protein 3 isoform 1 |
NCBI Synonym Full Names: | piwi-like RNA-mediated gene silencing 3 |
NCBI Official Symbol: | PIWIL3 |
NCBI Official Synonym Symbols: | HIWI3 |
NCBI Protein Information: | piwi-like protein 3; piwi-like 3 |
UniProt Protein Name: | Serine protease HTRA3 |
UniProt Synonym Protein Names: | High-temperature requirement factor A3; Pregnancy-related serine protease |
Protein Family: | Serine protease |
UniProt Gene Name: | HTRA3 |
UniProt Entry Name: | HTRA3_HUMAN |
Antibodies |
Anti-PIWIL-3 Antibody (CAB13203) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |