PIM2 Antibody (PACO15683)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO15683
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PIM2 Antibody (PACO15683) |
Antibody SKU: | PACO15683 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human PIM2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15683(PIM2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. |
Synonyms: | pim-2 oncogene |
UniProt Protein Function: | Pim2: a Ca(2 )/calmodulin-dependent protein kinase of the PIM family. Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. |
UniProt Protein Details: | Protein type:Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Oncoprotein; EC 2.7.11.1; CAMK group; PIM family Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytoplasm Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: cell proliferation; G1/S transition of mitotic cell cycle; male meiosis; negative regulation of apoptosis; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of mitotic cell cycle; response to virus |
NCBI Summary: | This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009] |
UniProt Code: | Q9P1W9 |
NCBI GenInfo Identifier: | 20139243 |
NCBI Gene ID: | 11040 |
NCBI Accession: | Q9P1W9.1 |
UniProt Secondary Accession: | Q9P1W9,Q99739, A8K4G6, |
UniProt Related Accession: | Q9P1W9 |
Molecular Weight: | 34,190 Da |
NCBI Full Name: | Serine/threonine-protein kinase pim-2 |
NCBI Synonym Full Names: | Pim-2 proto-oncogene, serine/threonine kinase |
NCBI Official Symbol: | PIM2 |
NCBI Protein Information: | serine/threonine-protein kinase pim-2 |
UniProt Protein Name: | Serine/threonine-protein kinase pim-2 |
UniProt Synonym Protein Names: | Pim-2h |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | PIM2 |
UniProt Entry Name: | PIM2_HUMAN |
Antibodies | ELISA Kits |
Anti-PIM2 Antibody (CAB15598) | Human PIM2 (Serine/threonine-protein kinase pim-2) ELISA Kit (HUFI07219) |
Anti-PIM2 Antibody (CAB9230) | |
PIM2 Antibody (PACO03376) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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