PIK3R3 Antibody (PACO19199)
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주문- SKU:
- PACO19199
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PIK3R3 Antibody (PACO19199) |
Antibody SKU: | PACO19199 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human PIK3R3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19199(PIK3R3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Mouse brain tissue, human fetal brain tissue, mouse testis tissue, hela cells, human fetal kidney tissue, Primary antibody: PACO19199(PIK3R3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19199(PIK3R3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related compounds at the 3’ position. PI 3-kinase p55 (PIK3R3) is comprised of a catalytic subunit and a regulatory subunit. The human p55 protein is composed of a rare amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains. PI 3-kinase p55 mRNAs are expressed in most human fetal and adult tissues; predominant expression is observed in the adult testis. Splice variant(s) of PI 3-kinase p55 have been identified; one of which has a deletion of 36 amino acid, at the amino terminus and another which has an insertion of 59 amino acid, at position 256 between the SH2 domains. Research suggests that PI 3-kinase p55 interacts with the IGFIR (Insulin-like growth factor-I receptor) and IR (Insulin receptor) and may be involved in PI 3-kinase activation by these receptors. |
Synonyms: | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
UniProt Protein Function: | PIK3R3: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Belongs to the PI3K p85 subunit family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Kinase, lipid Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytosol; phosphoinositide 3-kinase complex Molecular Function:protein binding; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; regulation of phosphoinositide 3-kinase activity |
NCBI Summary: | Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016] |
UniProt Code: | Q92569 |
NCBI GenInfo Identifier: | 317373310 |
NCBI Gene ID: | 8503 |
NCBI Accession: | Q92569.2 |
UniProt Related Accession: | Q92569 |
Molecular Weight: | |
NCBI Full Name: | Phosphatidylinositol 3-kinase regulatory subunit gamma |
NCBI Synonym Full Names: | phosphoinositide-3-kinase regulatory subunit 3 |
NCBI Official Symbol: | PIK3R3 |
NCBI Official Synonym Symbols: | p55; p55PIK; p55-GAMMA |
NCBI Protein Information: | phosphatidylinositol 3-kinase regulatory subunit gamma |
UniProt Protein Name: | Phosphatidylinositol 3-kinase regulatory subunit gamma |
UniProt Synonym Protein Names: | Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK |
UniProt Gene Name: | PIK3R3 |
UniProt Entry Name: | P55G_HUMAN |
Antibodies |
Anti-PIK3R3 Antibody (CAB17322) |
Anti-PIK3R3 Antibody (CAB7942) |
Anti-PIK3R3 Antibody (CAB17112) |
Anti-PI 3 Kinase p55 gamma Antibody (CAB3980) |
PIK3R3 Antibody (PACO11249) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |