Phospho-ZYX (S142) Antibody (PACO05342)
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주문- SKU:
- PACO05342
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-ZYX (S142) Antibody (PACO05342) |
Antibody SKU: | PACO05342 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from human Zyxin around the phosphorylation site of S142. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ZYX; Zyxin; Zyxin-2 |
UniProt Protein Function: | Zyxin: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 7q32 Cellular Component: focal adhesion; cell-cell adherens junction; integral to plasma membrane; cytoplasm; stress fiber; plasma membrane; nucleus Molecular Function:protein binding; zinc ion binding Biological Process: integrin-mediated signaling pathway; cell-cell signaling; viral reproduction; transforming growth factor beta receptor signaling pathway; cell-matrix adhesion; regulation of inflammatory response; stress fiber formation; signal transduction; cell adhesion |
NCBI Summary: | Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15942 |
NCBI GenInfo Identifier: | 2497677 |
NCBI Gene ID: | 7791 |
NCBI Accession: | Q15942.1 |
UniProt Secondary Accession: | Q15942,Q6I9S4, A4D2G6, B4DQX7, |
UniProt Related Accession: | Q15942 |
Molecular Weight: | 572 |
NCBI Full Name: | Zyxin |
NCBI Synonym Full Names: | zyxin |
NCBI Official Symbol: | ZYX |
NCBI Official Synonym Symbols: | ESP-2; HED-2 |
NCBI Protein Information: | zyxin; zyxin-2 |
UniProt Protein Name: | Zyxin |
UniProt Synonym Protein Names: | Zyxin-2 |
Protein Family: | Zyxin |
UniProt Gene Name: | ZYX |
UniProt Entry Name: | ZYX_HUMAN |