Phospho-TP73 (Tyr99) Antibody (PACO23847)
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주문- SKU:
- PACO23847
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-TP73 (Tyr99) Antibody (PACO23847) |
Antibody SKU: | PACO23847 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Peptide sequence around phosphorylation site of tyrosine 99 (S-P-Y(p)-A-Q) derived from Human P73. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from 293 cells untreated or treated with UV using p73(Phospho-Tyr99) Antibody. |
Background: | This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. |
Synonyms: | TP73; TRP73; p53-related protein; p73-alpha; |
UniProt Protein Function: | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. |
NCBI Summary: | This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011] |
UniProt Code: | O15350 |
NCBI GenInfo Identifier: | 8928244 |
NCBI Gene ID: | 7161 |
NCBI Accession: | O15350.1 |
UniProt Secondary Accession: | O15350,O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5 Q8TDY6, B7Z7J4, B7Z8Z1, B7Z9C1, C9J521, |
UniProt Related Accession: | O15350 |
Molecular Weight: | 61,694 Da |
NCBI Full Name: | Tumor protein p73 |
NCBI Synonym Full Names: | tumor protein p73 |
NCBI Official Symbol: | TP73 |
NCBI Official Synonym Symbols: | P73 |
NCBI Protein Information: | tumor protein p73 |
UniProt Protein Name: | Tumor protein p73 |
UniProt Synonym Protein Names: | p53-like transcription factor; p53-related protein |
Protein Family: | Tumor protein |
UniProt Gene Name: | TP73 |
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