Phospho-STAT6 (Thr645) Antibody (PACO24242)
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주문- SKU:
- PACO24242
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-STAT6 (Thr645) Antibody (PACO24242) |
Antibody SKU: | PACO24242 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:100 |
Species Reactivity: | Human |
Immunogen: | Peptide sequence around phosphorylation site of threonine 645 (P-A-T(p)-I-K) derived from Human STAT6. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6(Phospho-Thr645) Antibody(left) or the same antibody preincubated with blocking peptide(right). | |
Western blot analysis of extracts from Hela cells, treated with IL-4 or calf intestinal phosphatase (CIP), using STAT6 (Phospho-Thr645) Antibody. |
Background: | Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. |
Synonyms: | IL-4-STAT; STAT6B; STAT6C |
UniProt Protein Function: | STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nucleoplasm Molecular Function:identical protein binding; protein binding; protein phosphatase binding; signal transducer activity; transcription factor activity Biological Process: mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
UniProt Code: | P42226 |
NCBI GenInfo Identifier: | 1174459 |
NCBI Gene ID: | 6778 |
NCBI Accession: | P42226.1 |
UniProt Secondary Accession: | P42226,Q5FBW5, Q71UP4, A8K316, B7ZA27, F5GXI9, |
UniProt Related Accession: | P42226 |
Molecular Weight: | |
NCBI Full Name: | Signal transducer and activator of transcription 6 |
NCBI Synonym Full Names: | signal transducer and activator of transcription 6 |
NCBI Official Symbol: | STAT6 |
NCBI Official Synonym Symbols: | STAT6B; STAT6C; D12S1644; IL-4-STAT |
NCBI Protein Information: | signal transducer and activator of transcription 6 |
UniProt Protein Name: | Signal transducer and activator of transcription 6 |
UniProt Synonym Protein Names: | IL-4 Stat |
Protein Family: | Signal transducer and transcription activator |
UniProt Gene Name: | STAT6 |
UniProt Entry Name: | STAT6_HUMAN |
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