Phospho-STAT2 (Y690) Antibody (PACO00309)
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주문- SKU:
- PACO00309
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-STAT2 (Y690) Antibody |
Antibody SKU: | PACO00309 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Rat |
Immunogen: | synthesized peptide derived from human Stat2 around the phosphorylation site of Y690. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | STAT2; Signal transducer and activator of transcription 2; p113 |
UniProt Protein Function: | STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:DNA binding; identical protein binding; protein binding; signal transducer activity; transcription factor activity Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; JAK-STAT cascade; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction |
NCBI Summary: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | P52630 |
NCBI GenInfo Identifier: | 1711552 |
NCBI Gene ID: | 6773 |
NCBI Accession: | P52630.1 |
UniProt Secondary Accession: | P52630,Q16430, Q16431, Q9UDL4, B4DLC7, G3V2M6, |
UniProt Related Accession: | P52630 |
Molecular Weight: | 97,457 Da |
NCBI Full Name: | Signal transducer and activator of transcription 2 |
NCBI Synonym Full Names: | signal transducer and activator of transcription 2 |
NCBI Official Symbol: | STAT2 |
NCBI Official Synonym Symbols: | P113; IMD44; ISGF-3; STAT113 |
NCBI Protein Information: | signal transducer and activator of transcription 2 |
UniProt Protein Name: | Signal transducer and activator of transcription 2 |
UniProt Synonym Protein Names: | p113 |
Protein Family: | Signal transducer and activator of transcription |
UniProt Gene Name: | STAT2 |
UniProt Entry Name: | STAT2_HUMAN |