Phospho-REL (S503) Antibody (PACO03063)
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주문- SKU:
- PACO03063
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-REL (S503) Antibody |
Antibody SKU: | PACO03063 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from human c-Rel around the phosphorylation site of S503. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | REL; Proto-oncogene c-Rel |
UniProt Protein Function: | REL: a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. |
UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: cytosol; nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; protein binding; transcription factor activity Biological Process: cytokine production; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; negative regulation of interferon-beta production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; response to cytokine stimulus; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] |
UniProt Code: | Q04864 |
NCBI GenInfo Identifier: | 548720 |
NCBI Gene ID: | 5966 |
NCBI Accession: | Q04864.1 |
UniProt Secondary Accession: | Q04864,Q17RU2, Q2PNZ7, Q6LDY0, |
UniProt Related Accession: | Q04864 |
Molecular Weight: | 65,225 Da |
NCBI Full Name: | Proto-oncogene c-Rel |
NCBI Synonym Full Names: | v-rel avian reticuloendotheliosis viral oncogene homolog |
NCBI Official Symbol: | REL |
NCBI Official Synonym Symbols: | C-Rel |
NCBI Protein Information: | proto-oncogene c-Rel |
UniProt Protein Name: | Proto-oncogene c-Rel |
Protein Family: | Nuclear factor |
UniProt Gene Name: | REL |
UniProt Entry Name: | REL_HUMAN |