Phospho-RAD17 (S645) Antibody (PACO00279)
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주문- SKU:
- PACO00279
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-RAD17 (S645) Antibody |
Antibody SKU: | PACO00279 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | synthesized peptide derived from human Rad17 around the phosphorylation site of S645. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | RAD17; R24L; Cell cycle checkpoint protein RAD17; hRad17; RF-C/activator 1 homolog |
UniProt Protein Function: | RAD17: a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. Binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. Phosphorylated and activated after DNA damage, inducing cell cycle G2 arrest. Eight alternatively spliced variants have been reported. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 5q13 Cellular Component: nucleoplasm; chromosome, telomeric region; nucleus Molecular Function:protein binding; ATP binding Biological Process: regulation of phosphorylation; negative regulation of DNA replication; mitotic cell cycle checkpoint; DNA damage checkpoint; DNA repair; DNA replication; DNA replication checkpoint; response to DNA damage stimulus |
NCBI Summary: | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013] |
UniProt Code: | O75943 |
NCBI GenInfo Identifier: | 62287484 |
NCBI Gene ID: | 5884 |
NCBI Accession: | O75943.2 |
UniProt Secondary Accession: | O75943,O75714, Q7Z3S4, Q9UNK7, Q9UNR7, Q9UNR8, Q9UPF5 A8K8X2, D3DWA5, |
UniProt Related Accession: | O75943 |
Molecular Weight: | 681 |
NCBI Full Name: | Cell cycle checkpoint protein RAD17 |
NCBI Synonym Full Names: | RAD17 homolog (S. pombe) |
NCBI Official Symbol: | RAD17 |
NCBI Official Synonym Symbols: | CCYC; R24L; RAD24; HRAD17; RAD17SP |
NCBI Protein Information: | cell cycle checkpoint protein RAD17; RAD1 homolog; Rad17-like protein; RF-C activator 1 homolog; RF-C/activator 1 homolog |
UniProt Protein Name: | Cell cycle checkpoint protein RAD17 |
UniProt Synonym Protein Names: | RF-C/activator 1 homolog |
Protein Family: | Checkpoint protein |
UniProt Gene Name: | RAD17 |
UniProt Entry Name: | RAD17_HUMAN |