Phospho-PRKCQ (T538) Antibody (PACO04740)
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주문- SKU:
- PACO04740
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-PRKCQ (T538) Antibody |
Antibody SKU: | PACO04740 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from human PKC Theta around the phosphorylation site of T538. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | PRKCQ; PRKCT; Protein kinase C theta type; nPKC-theta |
UniProt Protein Function: | PKCT: an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; PKC family; Delta subfamily Chromosomal Location of Human Ortholog: 10p15 Cellular Component: plasma membrane; immunological synapse; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ubiquitin-protein ligase activity; ATP binding Biological Process: positive regulation of interleukin-17 production; axon guidance; phototransduction, visible light; platelet activation; apoptosis; positive regulation of interleukin-2 biosynthetic process; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; protein ubiquitination; protein amino acid phosphorylation; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; rhodopsin mediated signaling; positive regulation of interleukin-4 production; regulation of rhodopsin mediated signaling; regulation of transcription, DNA-dependent; innate immune response; positive regulation of T cell proliferation; regulation of cell growth; positive regulation of T cell activation; inflammatory response; blood coagulation; cell structure disassembly during apoptosis |
NCBI Summary: | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q04759 |
NCBI GenInfo Identifier: | 334848126 |
NCBI Gene ID: | 5588 |
NCBI Accession: | NP_001229342.1 |
UniProt Secondary Accession: | Q04759,Q14DH6, Q3MJF1, Q64FY5, Q9H508, Q9H549, |
UniProt Related Accession: | Q04759 |
Molecular Weight: | 81,865 Da |
NCBI Full Name: | protein kinase C theta type isoform 2 |
NCBI Synonym Full Names: | protein kinase C, theta |
NCBI Official Symbol: | PRKCQ |
NCBI Official Synonym Symbols: | PRKCT; nPKC-theta |
NCBI Protein Information: | protein kinase C theta type |
UniProt Protein Name: | Protein kinase C theta type |
UniProt Synonym Protein Names: | nPKC-theta |
UniProt Gene Name: | PRKCQ |
UniProt Entry Name: | KPCT_HUMAN |