Phospho-NFKBIB (S23) Antibody (PACO00226)
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주문- SKU:
- PACO00226
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-NFKBIB (S23) Antibody |
Antibody SKU: | PACO00226 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from human IKappaB-Beta around the phosphorylation site of S23. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9 |
UniProt Protein Function: | IkB-beta: a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA- dependent inactivation. Association with inhibitor kappa B- interacting Ras-like proteins 1 and 2 may also explain the slower degradation. Interacts with ligand-binding domain of thyroid hormone receptor-beta, inhibitor kappa B-interacting Ras-like protein 1, inhibitor kappa B-interacting protein Ras2, p65 (RELA) and c-Rel. Expressed in all tissues examined. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cytosol; nucleus Molecular Function:protein binding; signal transducer activity; transcription coactivator activity Biological Process: transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; signal transduction; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; positive regulation of interferon type I production; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway |
NCBI Summary: | The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011] |
UniProt Code: | Q15653 |
NCBI GenInfo Identifier: | 57015399 |
NCBI Gene ID: | 4793 |
NCBI Accession: | Q15653.2 |
UniProt Secondary Accession: | Q15653,Q96BJ7, A8K3F4, |
UniProt Related Accession: | Q15653 |
Molecular Weight: | 356 |
NCBI Full Name: | NF-kappa-B inhibitor beta |
NCBI Synonym Full Names: | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
NCBI Official Symbol: | NFKBIB |
NCBI Official Synonym Symbols: | IKBB; TRIP9 |
NCBI Protein Information: | NF-kappa-B inhibitor beta; ikB-B; TRIP-9; ikB-beta; ikappaBbeta; NF-kappa-BIB; I-kappa-B-beta; TR-interacting protein 9; thyroid receptor-interacting protein 9 |
UniProt Protein Name: | NF-kappa-B inhibitor beta |
UniProt Synonym Protein Names: | I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9 |
Protein Family: | NF-kappa-B inhibitor |
UniProt Gene Name: | NFKBIB |
UniProt Entry Name: | IKBB_HUMAN |