UniProt Protein Function: | Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. |
NCBI Summary: | The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O94916 |
NCBI GenInfo Identifier: | 9087151 |
NCBI Gene ID: | 10725 |
NCBI Accession: | O94916.1 |
UniProt Secondary Accession: | O94916,O95693, Q7LA65, Q969Q8, Q96QH3, Q9UN18, A2RRB4 A6H8V5, E9PHR7, |
UniProt Related Accession: | O94916 |
Molecular Weight: | 167,808 Da |
NCBI Full Name: | Nuclear factor of activated T-cells 5 |
NCBI Synonym Full Names: | nuclear factor of activated T-cells 5, tonicity-responsive |
NCBI Official Symbol: | NFAT5 |
NCBI Official Synonym Symbols: | NFATZ; OREBP; NF-AT5; NFATL1; TONEBP |
NCBI Protein Information: | nuclear factor of activated T-cells 5 |
UniProt Protein Name: | Nuclear factor of activated T-cells 5 |
UniProt Synonym Protein Names: | T-cell transcription factor NFAT5; Tonicity-responsive enhancer-binding protein; TonE-binding protein; TonEBP |
Protein Family: | Nuclear factor of activated T-cells |
UniProt Gene Name: | NFAT5 |
UniProt Entry Name: | NFAT5_HUMAN |