Phospho-NBN (S278) Antibody (PACO04397)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO04397
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-NBN (S278) Antibody |
Antibody SKU: | PACO04397 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from human Nibrin around the phosphorylation site of S278. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | NBN; NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1 |
UniProt Protein Function: | NBS1: a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome. |
UniProt Protein Details: | Protein type:Cell cycle regulation; DNA repair, damage Chromosomal Location of Human Ortholog: 8q21 Cellular Component: cytosol; Mre11 complex; nuclear chromosome, telomeric region; nuclear inclusion body; nucleolus; nucleoplasm; nucleus; PML body; replication fork Molecular Function:ATP-dependent DNA helicase activity; damaged DNA binding; protein binding; protein N-terminus binding; transcription factor binding Biological Process: blastocyst growth; cell cycle arrest; cell proliferation; DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator; DNA duplex unwinding; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; double-strand break repair via synthesis-dependent strand annealing; isotype switching; meiotic cell cycle; mitotic cell cycle checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; neuromuscular process controlling balance; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of DNA replication initiation; telomere maintenance; telomeric 3' overhang formation Disease: Aplastic Anemia; Leukemia, Acute Lymphoblastic; Nijmegen Breakage Syndrome |
NCBI Summary: | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60934 |
NCBI GenInfo Identifier: | 74762960 |
NCBI Gene ID: | 4683 |
NCBI Accession: | O60934.1 |
UniProt Secondary Accession: | O60934,O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2, B2R626 B2RNC5, |
UniProt Related Accession: | O60934 |
Molecular Weight: | 84,959 Da |
NCBI Full Name: | Nibrin |
NCBI Synonym Full Names: | nibrin |
NCBI Official Symbol: | NBN |
NCBI Official Synonym Symbols: | ATV; NBS; P95; NBS1; AT-V1; AT-V2 |
NCBI Protein Information: | nibrin |
UniProt Protein Name: | Nibrin |
UniProt Synonym Protein Names: | Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1 |
Protein Family: | Nibrin |
UniProt Gene Name: | NBN |
UniProt Entry Name: | NBN_HUMAN |