Phospho-MKNK1 (T250) Antibody (PACO05996)
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주문- SKU:
- PACO05996
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-MKNK1 (T250) Antibody (PACO05996) |
Antibody SKU: | PACO05996 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:20000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human Mnk1 around the phosphorylation site of T250. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MKNK1; MNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1 |
UniProt Protein Function: | Mnk1: a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Translation; Protein kinase, CAMK; CAMK group; MAPKAPK family; MNK subfamily Chromosomal Location of Human Ortholog: 1p33 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity Biological Process: fibroblast growth factor receptor signaling pathway; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation |
NCBI Summary: | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q9BUB5 |
NCBI GenInfo Identifier: | 30316115 |
NCBI Gene ID: | 8569 |
NCBI Accession: | Q9BUB5.1 |
UniProt Secondary Accession: | Q9BUB5,O00312, Q5TC06, Q5TC07, Q6V0N6, D3DQ20, D3DQ21 |
UniProt Related Accession: | Q9BUB5 |
Molecular Weight: | 39,104 Da |
NCBI Full Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
NCBI Synonym Full Names: | MAP kinase interacting serine/threonine kinase 1 |
NCBI Official Symbol: | MKNK1 |
NCBI Official Synonym Symbols: | MNK1 |
NCBI Protein Information: | MAP kinase-interacting serine/threonine-protein kinase 1 |
UniProt Protein Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
UniProt Synonym Protein Names: | MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1 |
Protein Family: | MAP kinase-interacting serine/threonine-protein kinase |
UniProt Gene Name: | MKNK1 |
UniProt Entry Name: | MKNK1_HUMAN |