Phospho-MDC1 (S513) Antibody (PACO05798)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO05798
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-MDC1 (S513) Antibody (PACO05798) |
Antibody SKU: | PACO05798 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:5000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from human MDC1 around the phosphorylation site of S513. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MDC1; KIAA0170; NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1 |
UniProt Protein Function: | MDC1: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 6p21.33 Cellular Component: chromosome; focal adhesion; nuclear body; nucleoplasm; nucleus Molecular Function:protein binding; protein C-terminus binding Biological Process: double-strand break repair via nonhomologous end joining; intra-S DNA damage checkpoint |
NCBI Summary: | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14676 |
NCBI GenInfo Identifier: | 68565390 |
NCBI Gene ID: | 9656 |
NCBI Accession: | Q14676.3 |
UniProt Secondary Accession: | Q14676,Q0EFC2, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83 A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, |
UniProt Related Accession: | Q14676 |
Molecular Weight: | 227kDa |
NCBI Full Name: | Mediator of DNA damage checkpoint protein 1 |
NCBI Synonym Full Names: | mediator of DNA damage checkpoint 1 |
NCBI Official Symbol: | MDC1 |
NCBI Official Synonym Symbols: | NFBD1 |
NCBI Protein Information: | mediator of DNA damage checkpoint protein 1 |
UniProt Protein Name: | Mediator of DNA damage checkpoint protein 1 |
UniProt Synonym Protein Names: | Nuclear factor with BRCT domains 1 |
Protein Family: | Mediator of DNA damage checkpoint protein |
UniProt Gene Name: | MDC1 |