Phospho-HGS (Y216) Antibody (PACO00216)
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주문- SKU:
- PACO00216
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-HGS (Y216) Antibody |
Antibody SKU: | PACO00216 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from human Hrs around the phosphorylation site of Y216. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | HGS; HRS; Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110 |
UniProt Protein Function: | Hrs: a zinc finger protein which is rapidly tyrosine phosphorylated in cells stimulated with various growth factors. Hrs mRNA is expressed in all the human adult and fetal tissues tested. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q25 Cellular Component: cytoplasm; cytosol; early endosome; early endosome membrane; endosome; intracellular membrane-bound organelle Molecular Function:metal ion binding; protein binding; protein domain specific binding Biological Process: autophagy; endosome transport; epidermal growth factor receptor signaling pathway; membrane invagination; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; post-Golgi vesicle-mediated transport; protein targeting to lysosome; regulation of MAP kinase activity; regulation of protein catabolic process; signal transduction |
NCBI Summary: | The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] |
UniProt Code: | O14964 |
NCBI GenInfo Identifier: | 71152119 |
NCBI Gene ID: | 9146 |
NCBI Accession: | O14964.1 |
UniProt Secondary Accession: | O14964,Q9NR36, |
UniProt Related Accession: | O14964 |
Molecular Weight: | 76,376 Da |
NCBI Full Name: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
NCBI Synonym Full Names: | hepatocyte growth factor-regulated tyrosine kinase substrate |
NCBI Official Symbol: | HGS |
NCBI Official Synonym Symbols: | HRS |
NCBI Protein Information: | hepatocyte growth factor-regulated tyrosine kinase substrate |
UniProt Protein Name: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
UniProt Synonym Protein Names: | Hrs |
Protein Family: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
UniProt Gene Name: | HGS |
UniProt Entry Name: | HGS_HUMAN |