Phospho-HDAC2 (S394) Antibody (PACO06156)
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주문- SKU:
- PACO06156
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-HDAC2 (S394) Antibody (PACO06156) |
Antibody SKU: | PACO06156 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | Synthesized peptide derived from human HDAC2 around the phosphorylation site of S394. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of NIH-3T3 cells using Phospho-HDAC2 (S394) Polyclonal Antibody. | |
Western Blot analysis of 3T3 cells using Phospho-HDAC2 (S394) Polyclonal Antibody. |
Synonyms: | HDAC2; Histone deacetylase 2; HD2 |
UniProt Protein Function: | HDAC2: a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
UniProt Protein Details: | Protein type:EC 3.5.1.98; Transcription, coactivator/corepressor; Deacetylase; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleoplasm; heterochromatin; transcription factor complex; protein complex; Sin3 complex; ESC/E(Z) complex; cytoplasm; nuclear chromatin; replication fork; NuRD complex; nucleus Molecular Function:deacetylase activity; nucleosomal DNA binding; protein deacetylase activity; transcription factor binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; heat shock protein binding; chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor activity Biological Process: establishment and/or maintenance of chromatin architecture; nerve growth factor receptor signaling pathway; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; negative regulation of cell cycle; cardiac muscle cell development; negative regulation of cardiac muscle cell proliferation; negative regulation of gene expression, epigenetic; positive regulation of cell proliferation; dendrite development; circadian regulation of gene expression; positive regulation of oligodendrocyte differentiation; response to drug; transcription, DNA-dependent; negative regulation of transcription factor activity; hippocampus development; histone deacetylation; regulation of protein kinase B signaling cascade; response to cocaine; odontogenesis of dentine-containing teeth; chromatin remodeling; maintenance of chromatin silencing; negative regulation of MHC class II biosynthetic process; ATP-dependent chromatin remodeling; epidermal cell differentiation; positive regulation of transcription factor activity; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; blood coagulation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis |
NCBI Summary: | This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] |
UniProt Code: | Q92769 |
NCBI GenInfo Identifier: | 68068066 |
NCBI Gene ID: | 3066 |
NCBI Accession: | Q92769.2 |
UniProt Secondary Accession: | Q92769,Q5SRI8, Q5SZ86, Q8NEH4, B3KRS5, B4DL58, E1P561 |
UniProt Related Accession: | Q92769 |
Molecular Weight: | 488 |
NCBI Full Name: | Histone deacetylase 2 |
NCBI Synonym Full Names: | histone deacetylase 2 |
NCBI Official Symbol: | HDAC2 |
NCBI Official Synonym Symbols: | HD2; RPD3; YAF1 |
NCBI Protein Information: | histone deacetylase 2; YY1-associated factor 1; transcriptional regulator homolog RPD3 |
UniProt Protein Name: | Histone deacetylase 2 |
UniProt Gene Name: | HDAC2 |
UniProt Entry Name: | HDAC2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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