Phospho-EZR (Y146) Antibody (PACO03125)
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주문- SKU:
- PACO03125
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-EZR (Y146) Antibody |
Antibody SKU: | PACO03125 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from human Ezrin around the phosphorylation site of Y146. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81 |
UniProt Protein Function: | Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: cortical cytoskeleton; extracellular space; microvillus; focal adhesion; basolateral plasma membrane; T-tubule; actin filament; cytosol; lipid raft; actin cytoskeleton; ruffle; extrinsic to membrane; membrane; apical part of cell; microvillus membrane; apical plasma membrane; nucleolus; plasma membrane; uropod; vesicle; filopodium Molecular Function:actin filament binding; protein domain specific binding; protein binding; cell adhesion molecule binding Biological Process: actin filament bundle formation; axon guidance; microvillus biogenesis; regulation of cell shape; leukocyte adhesion; filopodium formation; cytoskeletal anchoring; receptor internalization; membrane to membrane docking; establishment of epithelial cell polarity |
NCBI Summary: | The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P15311 |
NCBI GenInfo Identifier: | 125987826 |
NCBI Gene ID: | 7430 |
NCBI Accession: | P15311.4 |
UniProt Secondary Accession: | P15311,P23714, Q4VX75, Q96CU8, Q9NSJ4, E1P5A8, |
UniProt Related Accession: | P15311 |
Molecular Weight: | 586 |
NCBI Full Name: | Ezrin |
NCBI Synonym Full Names: | ezrin |
NCBI Official Symbol: | EZR |
NCBI Official Synonym Symbols: | CVL; CVIL; VIL2; HEL-S-105 |
NCBI Protein Information: | ezrin; p81; villin-2; cytovillin 2; villin 2 (ezrin); epididymis secretory protein Li 105 |
UniProt Protein Name: | Ezrin |
UniProt Synonym Protein Names: | Cytovillin; Villin-2; p81 |
Protein Family: | Ezrin |
UniProt Gene Name: | EZR |
UniProt Entry Name: | EZRI_HUMAN |