Phospho-ELK1 (S383) Antibody (PACO03607)
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주문- SKU:
- PACO03607
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-ELK1 (S383) Antibody |
Antibody SKU: | PACO03607 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IP |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IP:2-5ug |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from human Elk-1 around the phosphorylation site of S383. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ELK1; ETS domain-containing protein Elk-1 |
UniProt Protein Function: | ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: cell soma; dendrite; mitochondrion; nerve terminal; nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding; transcription factor activity Biological Process: cell differentiation; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to light stimulus; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012] |
UniProt Code: | P19419 |
NCBI GenInfo Identifier: | 12643407 |
NCBI Gene ID: | 2002 |
NCBI Accession: | P19419.2 |
UniProt Secondary Accession: | P19419,O75606, O95058, Q969X8, Q9UJM4, B2R7H4, |
UniProt Related Accession: | P19419 |
Molecular Weight: | |
NCBI Full Name: | ETS domain-containing protein Elk-1 |
NCBI Synonym Full Names: | ELK1, ETS transcription factor |
NCBI Official Symbol: | ELK1 |
NCBI Protein Information: | ETS domain-containing protein Elk-1 |
UniProt Protein Name: | ETS domain-containing protein Elk-1 |
Protein Family: | ETS domain-containing protein |
UniProt Gene Name: | ELK1 |
UniProt Entry Name: | ELK1_HUMAN |